Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study.

ABSTRACT:

Purpose

Intravenous vitamin C (IVC) is used in a variety of disorders with limited supporting pharmacokinetic data. Herein we report a pharmacokinetic study in healthy volunteers and cancer participants with IVC doses in the range of 1-100 g.

Methods

A pharmacokinetic study was conducted in 21 healthy volunteers and 12 oncology participants. Healthy participants received IVC infusions of 1-100 g; oncology participants received IVC infusions of 25-100 g. Serial blood and complete urine samples were collected pre-infusion and for 24 h post-infusion. Pharmacokinetic parameters were computed using noncompartmental methods. Adverse events were monitored during the study.

Results

In both cohorts, IVC exhibited first-order kinetics at doses up to 75 g. At 100 g, maximum conc

SUBMITTER: Chen P 

PROVIDER: S-EPMC9439974 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature