The physiology of experimental overfeeding in animals.

ABSTRACT:

Background

Body weight is defended by strong homeostatic forces. Several of the key biological mechanisms that counteract weight loss have been unraveled over the last decades. In contrast, the mechanisms that protect body weight and fat mass from becoming too high remain largely unknown. Understanding this aspect of energy balance regulation holds great promise for curbing the obesity epidemic. Decoding the physiological and molecular pathways that defend against weight gain can be achieved by an intervention referred to as 'experimental overfeeding'.

Scope of the review

In this review, we define experimental overfeeding and summarize the studies that have been conducted on animals. This field of research shows that experimental overfeeding induces a potent and prolonged hy

SUBMITTER: Ranea-Robles P 

PROVIDER: S-EPMC9440064 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature