Impact of overestimation of fractional flow reserve by adenosine on anatomical-functional mismatch.

ABSTRACT: Adenosine occasionally results in overestimation of fractional flow reserve (FFR) values, compared with other hyperemic stimuli. We aimed to elucidate the association of overestimation of FFR by adenosine with anatomically significant but functionally non-significant lesions (anatomical-functional mismatch) and its influence on reclassification of functional significance. Distal-to-aortic pressure ratio (Pd/Pa) was measured using adenosine (Pd/Pa_ADN) and papaverine (Pd/Pa_PAP) in 326 patients (326 vessels). The overestimation of FFR was calculated as Pd/Pa_ADN-Pd/Pa_PAP. The anatomical-functional mismatch was defined as diameter stenosis > 50% and Pd/Pa_ADN > 0.80. Reclassification was indicated by Pd/Pa_ADN > 0.80 and P

SUBMITTER: Matsumoto H 

PROVIDER: S-EPMC9440099 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature