A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis.

ABSTRACT: In Drosophila ovary, niche is composed of somatic cells, including terminal filament cells (TFCs), cap cells (CCs) and escort cells (ECs), which provide extrinsic signals to maintain stem cell renewal or initiate cell differentiation. Niche establishment begins in larval stages when terminal filaments (TFs) are formed, but the underlying mechanism for the development of TFs remains largely unknown. Here we report that transcription factor longitudinals lacking (Lola) is essential for ovary morphogenesis. We showed that Lola protein was expressed abundantly in TFCs and CCs, although also in other cells, and lola was required for the establishment of niche during larval stage. Importantly, we found that knockdown expression of lola induced apoptosis in adult ovary, and that lola affected adu

SUBMITTER: Zhao T 

PROVIDER: S-EPMC9440207 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature