Mechanosensitive expression of the mesenchymal subtype marker connective tissue growth factor in glioblastoma.

ABSTRACT: Mechanical forces created by the extracellular environment regulate biochemical signals that modulate the inter-related cellular phenotypes of morphology, proliferation, and migration. A stiff microenvironment induces glioblastoma (GBM) cells to develop prominent actin stress fibres, take on a spread morphology and adopt trapezoid shapes, when cultured in 2D, which are phenotypes characteristic of a mesenchymal cell program. The mesenchymal subtype is the most aggressive among the molecular GBM subtypes. Recurrent GBM have been reported to transition to mesenchymal. We therefore sought to test the hypothesis that stiffer microenvironments-such as those found in different brain anatomical structures and induced following treatment-contribute to the expression of markers characterising the m

SUBMITTER: Grundy TJ 

PROVIDER: S-EPMC9440209 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature