No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model.

ABSTRACT: With the rapid development of alternative methods based on the spirit of animal welfare, the publications of animal studies evaluating endpoints such as cancer have been extremely reduced. We performed a 26-week inhalation exposure studies of titanium dioxide nanoparticles (TiO₂ NPs) using CByB6F1-Tg(HRAS)2Jic (rasH2) mice model for detecting carcinogenicity. Male and female rasH2 mice were exposed to 2, 8 or 32 mg/m³ of TiO₂ NPs for 6 h/day, 5 days/week for 26 weeks. All tissues and blood were collected and subjected to biological and histopathological analyses. TiO₂ NPs exposure induced deposition of particles in lungs in a dose-dependent manner in each exposure group. Exposure to TiO₂ NPs, as well as other organs, did not increase t

SUBMITTER: Yamano S 

PROVIDER: S-EPMC9440215 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature