Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition.

ABSTRACT: The essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, microbiota participates in an interactive host-microbiota metabolic signaling, impacting metabolic phenotypes of the host. Dysbiosis of microbiota results in alteration of certain microbial and host metabolites. Identifying these markers could enhance early detection of certain diseases. We report LC-MS based non-targeted metabolic profiling that demonstrates a large effect of gut microbiota on mammalian tissue metabolites. It was hypothesized that gut microbiota influences the overall biochemistry of host metabolome and this effect is tissue-specific. Thirteen different tissues from germ-free (GF

SUBMITTER: Zarei I 

PROVIDER: S-EPMC9440220 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature