Spirulina polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice.

ABSTRACT: A polysaccharide obtained from Spirulina (PSP) and its effect on lung cancer in mice was investigated. Our results indicate that the tumor volume and weight of the lung cancer-bearing mice treated with PSP decreased significantly. Metabolite analysis showed that 27 differential accumulated metabolites (DAMs) changed significantly, in which 24 DAMs increased while 3 DAMs decreased. KEGG enrichment results showed that these differential metabolites were enriched significantly in the high-affinity IgE receptor (FcεRI) signaling pathway and arachidonic acid metabolism. In addition, PSP modulated gut microbiota of the lung cancer-bearing mice. PSP increased the abundance of Lactobacillus, Allobaculum, Alloprevotella, and Olsenella, decreasing Bacteroides

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9440268 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature