3D bioprinting of nanoparticle-laden hydrogel scaffolds with enhanced antibacterial and imaging properties.

ABSTRACT: Biomaterial-associated microbial contaminations in biologically conducive three-dimensional (3D) tissue-engineered constructs have significantly limited the clinical applications of scaffold systems. To prevent such infections, antimicrobial biomaterials are rapidly evolving. Yet, the use of such materials in bioprinting-based approaches of scaffold fabrication has not been examined. This study introduces a new generation of bacteriostatic gelatin methacryloyl (GelMA)-based bioinks, incorporated with varying doses of antibacterial superparamagnetic iron oxide nanoparticles (SPIONs). The SPION-laden GelMA scaffolds showed significant resistance against the Staphylococcus aureus growth, while providing a contrast in magnetic resonance imaging. We simulated the bacterial contamination

SUBMITTER: Theus AS 

PROVIDER: S-EPMC9440295 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature