Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity.

ABSTRACT:

Objective

Maternal obesity increases the incidence of excess adiposity in newborns, resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to maternal hyperglycemia; however, this hypothesis does not account for the increased adiposity seen in newborns of mothers with obesity who have euglycemia. We aimed to explore the placental response to maternal hyperinsulinemia and the effect of insulin-like growth factor 2 (IGF-2) in promoting fetal adiposity by increasing storage and availability of nutrients to the fetus.

Methods

We used placental villous explants and isolated trophoblasts from normal weight and obese women to assess the effect of insulin and IGF-2 on triglyceride content and insulin receptor signaling. Stable isotope tracer m

SUBMITTER: Anam AK 

PROVIDER: S-EPMC9440306 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature