FMRI informed voxel-based lesion analysis to identify lesions associated with right-hemispheric activation in aphasia recovery.

ABSTRACT: Several mechanisms have been attributed to post-stroke loss and recovery of language functions. However, the significance and timing of domain-general and homotopic right-hemispheric activation is controversial. We aimed to examine the effect of left-hemispheric lesion location and time post-stroke on right-hemispheric activation. Voxel-based lesion analyses were informed by auditory language-related fMRI activation of 71 patients with left middle cerebral artery stroke examined longitudinally in the acute, subacute and early chronic phase. Language activation was determined in several right-hemispheric regions of interest and served as regressor of interest for voxel-based lesion analyses. We found that an acute to chronic increase of language activation in the right supplementary motor a

SUBMITTER: Schneider HR 

PROVIDER: S-EPMC9440420 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature