Development and application of a High-Resolution mass spectrometry method for the detection of fentanyl analogs in urine and serum.

ABSTRACT:

Introduction

The use of illicitly manufactured synthetic opioids, specifically fentanyl and its analogs, has escalated exponentially in the United States over the last decade. Due to the targeted nature of drug detection methods in clinical laboratories and the ever-evolving list of synthetic opioids of concern, alternative analytical approaches are needed.

Methods

Using the fentanyl analog screening (FAS) kit produced by the Centers for Disease Control and Prevention (CDC), we developed a liquid chromatography-high resolution mass spectrometry (LC-HRMS) synthetic opioid spectral library and data acquisition method using information dependent acquisition of product ion spectra. Chromatographic retention times, limits of detection and matrix effects, in urine and serum, for t

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9440429 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature