Correlation of the prognostic value of FNDC4 in glioblastoma with macrophage polarization.

ABSTRACT:

Background

Glioblastoma is among the most malignant tumors in the central nervous system and characterized by strong invasion and poor prognosis. Fibronectin type III domain-containing 4 (FNDC4) plays various important roles in the human body, including participating in cellular metabolism and inflammatory responses to cardiovascular diseases, influencing immune cells, and exerting anti-inflammatory effects; however, the role of FNDC4 in glioblastoma has not been reported.

Methods

In this study, bioinformatics databases, including TCGA, CGGA, GTEx, and TIMER, were used to analyze the differential expression of FNDC4 genes and cell survival, in addition to investigating its relationship with immune cell infiltration. Additionally, we overexpressed FNDC4 in glioblastoma cell l

SUBMITTER: Li H 

PROVIDER: S-EPMC9440505 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature