Comprehensive analysis of key genes and pathways for biological and clinical implications in thyroid-associated ophthalmopathy.

ABSTRACT:

Background

Thyroid-associated ophthalmopathy (TAO) is a common and organ-specific autoimmune disease. Early diagnosis and novel treatments are essential to improve the prognosis of TAO patients. Therefore, the current work was performed to identify the key genes and pathways for the biological and clinical implications of TAO through comprehensive bioinformatics analysis and a series of clinical validations.

Methods

GSE105149 and GSE185952 were obtained from the Gene Expression Omnibus (GEO) database for analysis. The data were normalized to identify the common differentially expressed genes (DEGs) between the two datasets, and the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to assess key pathways in TAO. Protein-p

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9440526 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature