Optimum flux rerouting for efficient production of naringenin from acetate in engineered Escherichia coli.

ABSTRACT:

Background

Microbial production of naringenin has received much attention owing to its pharmaceutical applicability and potential as a key molecular scaffold for various flavonoids. In the microbial fermentation, a cheap and abundant feedstock is required to achieve an economically feasible bioprocess. From this perspective, utilizing acetate for naringenin production could be an effective strategy, with the advantages of both low-cost and abundant feedstock. For the efficient production of naringenin using acetate, identification of the appropriate regulatory node of carbon flux in the biosynthesis of naringenin from acetate would be important. While acetyl-CoA is a key precursor for naringenin production, carbon flux between the TCA cycle and anaplerosis is effectively regulated

SUBMITTER: Kim DH 

PROVIDER: S-EPMC9440541 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature