Identification of early biomarkers of transcriptomics in alveolar macrophage for the prognosis of intubated ARDS patients.

ABSTRACT:

Background

Currently, the rate of morbidity and mortality in acute respiratory distress syndrome (ARDS) remains high. One of the potential reasons for the poor and ineffective therapies is the lack of early and credible indicator of risk prediction that would help specific treatment of severely affected ARDS patients. Nevertheless, assessment of the clinical outcomes with transcriptomics of ARDS by alveolar macrophage has not been performed.

Methods

The expression data GSE116560 was obtained from the Gene Expression Omnibus databases (GEO) in NCBI. This dataset consists of 68 BAL samples from 35 subjects that were collected within 48 h of ARDS. Differentially expressed genes (DEGs) of different outcomes were analyzed using R software. The top 10 DEGs that were up- or down-re

SUBMITTER: Shi S 

PROVIDER: S-EPMC9440545 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature