Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline.

ABSTRACT:

Background

Subjective cognitive decline (SCD) is a putative Alzheimer's disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in cognitive function and emotional responses and is generally aberrant in SCD. However, previous studies have mainly focused on static functional connectivity (sFC) by resting-state functional magnetic resonance imaging (fMRI) in SCD individuals, and it remains unclear whether hippocampal dynamic functional connectivity (dFC) changes exist in SCD and whether those changes are associated with subtle changes in cognitive function or affect.

Methods

Seventy SCD patients and 65 healthy controls were recruited. Demographic data, comprehensive neuropsychology assessments, and resting-state fMRI data w

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9440588 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature