Detailed bladder cancer immunoprofiling reveals new clues for immunotherapeutic strategies.

ABSTRACT:

Objectives

Bladder cancer (BlCa) is the tenth most frequent malignancy worldwide and the costliest to treat and monitor. Muscle-invasive BlCa (MIBC) has a dismal prognosis, entailing the need for alternative therapies for the standard radical cystectomy. Checkpoint blockade immunotherapy has been approved for high-grade non-muscle-invasive BlCa (HG NMIBC) and metastatic disease, but its effectiveness in localised MIBC remains under scrutiny. Herein, we sought to characterise and compare the immune infiltrate of HG NMIBC and MIBC samples, including ICOS expression, a targetable immune checkpoint associated with regulatory T cell(T_regs)-mediated immunosuppression.

Methods

Immunohistochemistry for CD83, CD20, CD68, CD163, CD3, CD8, CD4, FoxP3/ICOS and PD-L1 was perfo

SUBMITTER: Viveiros N 

PROVIDER: S-EPMC9440624 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature