Human neural progenitors establish a diffusion barrier in the endoplasmic reticulum membrane during cell division.

ABSTRACT: Asymmetric segregation of cellular components regulates the fate and behavior of somatic stem cells. Similar to dividing budding yeast and precursor cells in Caenorhabditis elegans, it has been shown that mouse neural progenitors establish a diffusion barrier in the membrane of the endoplasmic reticulum (ER), which has been associated with asymmetric partitioning of damaged proteins and cellular age. However, the existence of an ER diffusion barrier in human cells remains unknown. Here, we used fluorescence loss in photobleaching (FLIP) imaging to show that human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived neural progenitor cells establish an ER diffusion barrier during cell division. The human ER diffusion barrier is regulated via lamin-dependent mechanism

SUBMITTER: Bin Imtiaz MK 

PROVIDER: S-EPMC9440750 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature