TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells.

ABSTRACT: Cell fate determination is a necessary and tightly regulated process for producing different cell types and structures during development. Cranial neural crest cells (CNCCs) are unique to vertebrate embryos and emerge from the neural plate borders into multiple cell lineages that differentiate into bone, cartilage, neurons and glial cells. We have previously reported that Irf6 genetically interacts with Twist1 during CNCC-derived tissue formation. Here, we have investigated the mechanistic role of Twist1 and Irf6 at early stages of craniofacial development. Our data indicate that TWIST1 is expressed in endocytic vesicles at the apical surface and interacts with β/δ-catenins during neural tube closure, and Irf6 is involved in defining neural fold borders by restricting AP2α expression. Twis

SUBMITTER: Bertol JW 

PROVIDER: S-EPMC9440756 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature