Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity?

ABSTRACT:

Background

The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case-control study with matched confounding variables on the salivary microbiome in CKD and the influence of diabetes and hypertension on the microbiome has never been reported.

Methods

In our study, we compared the salivary microbiome profile between patients with CKD and healthy controls (HC) using 16S ribosomal DNA sequencing and examine its association with diabetes, hypertension, and immunity.

Results

We observed that the bacterial community was skewed in the saliva of CKD, with increased Lautropia and Pseudomonas, and decreased Actinomyces, Prevotella, Prevo

SUBMITTER: Liu F 

PROVIDER: S-EPMC9441058 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature