Hyperthermia Improves Solubility of Intravesical Chemotherapeutic Agents.

ABSTRACT:

Background

Nearly 70% of all new cases of bladder cancer are non-muscle invasive disease, the treatment for which includes transurethral resection followed by intravesical therapy. Unfortunately, recurrence rates approach 50% in part due to poor intravesical drug delivery. Hyperthermia is frequently used as an adjunct to intravesical chemotherapy to improve drug delivery and response to treatment.

Objective

To assess the solubility profile of intravesical chemotherapies under varying conditions of pH and temperature.

Methods

Using microplate laser nephelometry we measured the solubility of three intravesical chemotherapy agents (mitomycin C, gemcitabine, and cisplatin) at varying physical conditions. Drugs were assessed at room temperature (23°C), body temperature (37

SUBMITTER: Grimberg DC 

PROVIDER: S-EPMC9441059 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature