Gene signatures, immune infiltration, and drug sensitivity based on a comprehensive analysis of m6a RNA methylation regulators in cervical cancer.

ABSTRACT:

Background

Cervical cancer is the fourth most common cancer in women. N⁶-dimethyladenosine (m⁶A) mRNA methylation is closely associated with cervical cancer.

Methods

Using TCGA database, we studied the expression and mutation of m⁶A-related genes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and obtained genetic characteristics based on an m⁶A risk model and prognostic value of m⁶A. We studied the effects of the m⁶A risk score on immune features and genomic changes of patients with CESC, evaluated the sensitivity of patients with CESC to different small-molecule drugs based on the m⁶A risk score, and established a clinical prediction model.

Results

Ten m⁶

SUBMITTER: Lu X 

PROVIDER: S-EPMC9441061 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature