A modified Sequential Organ Failure Assessment score for dengue: development, evaluation and proposal for use in clinical trials.

ABSTRACT:

Background

Dengue is a neglected tropical disease, for which no therapeutic agents have shown clinical efficacy to date. Clinical trials have used strikingly variable clinical endpoints, which hampers reproducibility and comparability of findings. We investigated a delta modified Sequential Organ Failure Assessment (delta mSOFA) score as a uniform composite clinical endpoint for use in clinical trials investigating therapeutics for moderate and severe dengue.

Methods

We developed a modified SOFA score for dengue, measured and evaluated its performance at baseline and 48 h after enrolment in a prospective observational cohort of 124 adults admitted to a tertiary referral hospital in Vietnam with dengue shock. The modified SOFA score included pulse pressure in the cardiovascul

SUBMITTER: McBride A 

PROVIDER: S-EPMC9441074 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature