Heterogeneity in Staphylococcus aureus Bacteraemia Clinical Trials Complicates Interpretation of Findings.
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ABSTRACT:
SUBMITTER: Dolby HW
PROVIDER: S-EPMC9441204 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Heterogeneity in Staphylococcus aureus Bacteraemia Clinical Trials Complicates Interpretation of Findings.
Dolby Heather W HW Clifford Sarah A SA Laurenson Ian F IF Fowler Vance G VG Russell Clark D CD
The Journal of infectious diseases 20220901 4
We systematically evaluated randomized-controlled trials (RCTs) for Staphylococcus aureus bacteremia (SAB). There was intertrial heterogeneity in cohort characteristics, including bacteremia source, complicated SAB, and comorbidities. Reporting of cohort characteristics was itself variable, including bacteremia source and illness severity. Selection bias was introduced by exclusion criteria relating to comorbidities, illness severity, infection types, and source control. Mortality was lower in R ...[more]
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