Role of cytochrome P450 for vitamin D metabolisms in patients with neurodegenerative disorders.

ABSTRACT:

Introduction

We previously reported lower serum 25-hydroxyvitamin D concentrations in patients with Alzheimer's disease (AD), Parkinson's disease (PD) and Multiple system atrophy (MSA) compared to healthy controls (HC), whereas 1,25-di-hydroxyvitamin D levels were solely lower in MSA patients. We investigate serum concentrations of P450 involved in Vitamin D(VD) hydroxylation to clarify the responsible hydroxylase for the low serum concentrations of VD metabolites.

Methods

A total of 79 individuals were enrolled including 20 HC, 20 AD, 19 PD and 20 MSA patients. The serum concentrations of P450 involved in VD hydroxylation were assayed by ELISA. The data were analyzed by the nonparametric Kruskal-Wallis test between groups.

Results

Though CYP2R1 and CYP27A1 mediate 25

SUBMITTER: Kakimoto A 

PROVIDER: S-EPMC9441335 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature