Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over the period of time. AD is characterized by cognitive dysfunctions, behavioural disability, and psychological impairments due to the accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles (NFT). Several research reports have shown that flavonoids are the polyphenolic compounds that significantly improve cognitive functions and inhibit or delay the amyloid beta aggregation or NFT formation in AD. Current research has uncovered that dietary use of flavonoid-rich food sources essentially increases intellectual abilities a

SUBMITTER: Minocha T 

PROVIDER: S-EPMC9441372 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature