Gut Microbiota Dysbiosis in the Development and Progression of Gastric Cancer.

ABSTRACT:

Objectives

This study aims to explore gut microbiota dysbiosis in the histological stages of gastric cancer (GC).

Methods

Feces samples and clinical characteristics were collected from patients with different stages of GC, including 15 superficial gastritis (SG), 13 atrophic gastritis (AG), 8 gastric mucosal atypical hyperplasia (GMAH), and 15 advanced GC cases. The diversity and composition of gut microbiota among the four groups were determined by sequencing the V4 region of bacterial 16S rRNA genes.

Results

Reduced gut microbial alpha diversity and altered dissimilarity of the microbial community structure were found among the four groups. In addition, 18 species, 6 species, 6 species, and 16 species of bacteria were enriched in the SG, AG, GMAH, and GC groups, res

SUBMITTER: Miao Y 

PROVIDER: S-EPMC9441395 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature