The Persistent Pain Transcriptome: Identification of Cells and Molecules Activated by Hyperalgesia.

ABSTRACT: During persistent pain, the dorsal spinal cord responds to painful inputs from the site of injury, but the molecular modulatory processes have not been comprehensively examined. Using transcriptomics and multiplex in situ hybridization, we identified the most highly regulated receptors and signaling molecules in rat dorsal spinal cord in peripheral inflammatory and post-surgical incisional pain models. We examined a time course of the response including acute (2 hours) and longer term (2 day) time points after peripheral injury representing the early onset and instantiation of hyperalgesic processes. From this analysis, we identify a key population of superficial dorsal spinal cord neurons marked by somatotopic upregulation of the opioid neuropeptide precursor prodynorphin, and 2 receptors

SUBMITTER: Sapio MR 

PROVIDER: S-EPMC9441406 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature