Quantitative Susceptibility Mapping of Brain Iron Deposition in Patients With Recurrent Depression.

ABSTRACT:

Objective

Recurrence is the most significant feature of depression and the relationship between iron and recurrent depression is still lack of direct evidence in vivo.

Methods

Twenty-one patients with depression and twenty control subjects were included. Gradient-recalled echo, T1 and T2 images were acquired using a 3.0T MRI system. After quantitative susceptibility mapping were reconstructed and standardized, a whole-brain and the regions of interest were respectively analyzed.

Results

Significant increases in susceptibility were found in multiple recurrent depression patients, which involved several brain regions (frontal lobes, temporal lobe structures, occipital lobes hippocampal regions, putamen, thalamus, cingulum, and cerebellum). Interestingly, no susceptibili

SUBMITTER: Duan X 

PROVIDER: S-EPMC9441458 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature