Alterations in Spontaneous Brain Activity in Drug-Naive First-Episode Schizophrenia: An Anatomical/Activation Likelihood Estimation Meta-Analysis.

ABSTRACT:

Objective

The etiology of schizophrenia is unknown and is associated with abnormal spontaneous brain activity. There are no consistent results regarding the change in spontaneous brain activity of people with schizophrenia. In this study, we determined the specific changes in the amplitude of low-frequency fluctuation/fractional amplitude of low-frequency fluctuation (ALFF/fALFF) and regional homogeneity (ReHo) in patients with drug-naïve first-episode schizophrenia (Dn-FES).

Methods

A comprehensive search of databases such as PubMed, Web of Science, and Embase was conducted to find articles on resting-state functional magnetic resonance imaging using ALFF/fALFF and ReHo in schizophrenia patients compared to healthy controls (HCs) and then, anatomical/activation likelihood e

SUBMITTER: Qiu X 

PROVIDER: S-EPMC9441467 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature