The aberrant dynamic amplitude of low-frequency fluctuations in melancholic major depressive disorder with insomnia.

ABSTRACT:

Background

Insomnia is considered one of the manifestations of sleep disorders, and its intensity is linked to the treatment effect or suicidal thoughts. Major depressive disorder (MDD) is classified into various subtypes due to heterogeneous symptoms. Melancholic MDD has been considered one of the most common subtypes with special sleep features. However, the brain functional mechanisms in melancholic MDD with insomnia remain unclear.

Materials and methods

Melancholic MDD and healthy controls (HCs, n = 46) were recruited for the study. Patients were divided into patients with melancholic MDD with low insomnia (mMDD-LI, n = 23) and patients with melancholic MDD with high insomnia (mMDD-HI, n = 30), according to the sleep disturbance subscale of the 17-it

SUBMITTER: Deng Z 

PROVIDER: S-EPMC9441487 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature