Cardiovascular outcomes of metformin use in patients with type 2 diabetes and chronic obstructive pulmonary disease.

ABSTRACT: Aim: To know whether metformin use has different influence on cardiovascular risks in patients with type 2 diabetes mellitus (T2DM) and chronic obstructive pulmonary disease (COPD) as compared with metformin no-use. Methods: This study employed a retrospective cohort study design. Using propensity score matching, we recruited 55 ,224 pairs of metformin users and nonusers from Taiwan's National Health Insurance Research Database between 1 January 2000, and 31 December 2017. Cox proportional-hazards models with robust standard error estimates were used to compare the risks of cardiovascular outcomes. Results: The mean study period of metformin users and nonusers was 11.04 (5.46) and 12.30 (4.85) years, respectively. Compared with the nonuse of metformin, the adjusted haz

SUBMITTER: Yen FS 

PROVIDER: S-EPMC9441545 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature