A cuproptosis and copper metabolism-related gene prognostic index for head and neck squamous cell carcinoma.

ABSTRACT:

Background

The purpose of this study was to identify the prognostic value of cuproptosis and copper metabolism-related genes, to clarify their molecular and immunological characteristics, and to elucidate their benefits in head and neck squamous cell carcinoma (HNSCC).

Methods

The details of human cuproptosis and copper metabolism-related genes were searched and filtered from the msigdb database and the latest literature. To identify prognostic genes associated with cuproptosis and copper metabolism, we used least absolute shrinkage and selection operator regression, and this coefficient was used to set up a prognostic risk score model. HNSCC samples were divided into two groups according to the median risk. Afterwards, the function and immune characteristics of these genes

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9441563 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature