Cyclic AMP and calcium signaling are involved in antipsychotic-induced diabetogenic effects in isolated pancreatic β cells of CD1 mice.

ABSTRACT:

Objectives

Antipsychotics (APs) are medications used for different psychological disorders. They can introduce diabetogenic effects through different mechanisms, including cyclic adenosine monophosphate (cAMP) and calcium (Ca²⁺) signaling pathways. However, this effect is poorly understood. Therefore, this study aimed to evaluate the effect of three widely used APs (chlorpromazine, haloperidol, and clozapine) on cAMP and Ca²⁺ signaling.

Methods

The local bioethics committee of Northern Border University approved the study. Pancreatic β-cells were isolated from male CD1 mice, and three drug stock solutions were made in different concentrations (0.1, 1, 10, and 100 μM). The levels of glucose-stimulated insulin secretion (GSIS) and cAMP as well as the acti

SUBMITTER: Al-Ghafari A 

PROVIDER: S-EPMC9441645 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature