Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal rats.

ABSTRACT: Germinal matrix hemorrhage (GMH) is a common complication in preterm infants and is associated with high risk of adverse neurodevelopmental outcomes. We used a rat GMH model and performed RNA sequencing to investigate the signaling pathways and biological processes following hemorrhage. GMH induced brain injury characterized by early hematoma and subsequent tissue loss. At 6 hours after GMH, gene expression indicated an increase in mitochondrial activity such as ATP metabolism and oxidative phosphorylation along with upregulation of cytoprotective pathways and heme metabolism. At 24 hours after GMH, the expression pattern suggested an increase in cell cycle progression and downregulation of neurodevelopmental-related pathways. At 72 hours after GMH, there was an increase in genes related t

SUBMITTER: Song J 

PROVIDER: S-EPMC9441725 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature