Identification of two rate-limiting steps in the degradation of partially folded immunoglobulin light chains.

ABSTRACT: Antibody monomers are produced from two immunoglobulin heavy chains and two light chains that are folded and assembled in the endoplasmic reticulum This process is assisted and monitored by components of the endoplasmic reticulum quality control machinery; an outcome made more fraught by the unusual genetic machinations employed to produce a seemingly unlimited antibody repertoire. Proper functioning of the adaptive immune system is as dependent on the success of this operation, as it is on the ability to identify and degrade those molecules that fail to reach their native state. In this study, two rate-limiting steps were identified in the degradation of a non-secreted κ light chain. Both focus on the constant domain (C_L), which has evolved to fold rapidly and very stably to se

SUBMITTER: Mann MJ 

PROVIDER: S-EPMC9441772 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature