Short- and long-term outcome of allogeneic stem cell transplantation in infants: A single-center experience over 20 years.

ABSTRACT:

Introduction

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a treatment method for a wide range of malignant and non-malignant diseases. Infants constitute a distinct patient group, especially due to their organ immaturity and differences in drug metabolism. The present paper aims to analyse the short- and long-term outcomes after allo-HSCT in infants.

Material and methods

In the study period, 67 patients under 12 months of age underwent allo-HSCT. This study is a retrospective analysis of patient medical records, in the form of paper and electronic documentation.

Results

The probability of 5-year OS was 69% and 72% in patients with malignant and non-malignant diseases, respectively. The allo-HSCT from a matched donor was associated with improved OS

SUBMITTER: Miskiewicz-Bujna J 

PROVIDER: S-EPMC9441786 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature