Coffee and caffeine consumption and risk of renal cell carcinoma: A Mendelian randomization study.

ABSTRACT:

Background

The association between coffee and caffeine consumption and the risk of renal cell carcinoma was inconsistent among observational studies, and whether these observed associations were causal remained unclear. Therefore, we performed two-sample Mendelian randomization (MR) study to assess the causal nature of the association.

Materials and methods

In this study, 12 and two independent single nucleotide polymorphisms (SNPs) related to coffee and caffeine consumption at a genome-wide significance level of p < 5 × 10^-8 were used as instrumental variables (IVs), respectively. Summary-level data for renal cell carcinoma were taken from the FinnGen consortium with up to 174,977 individuals, and the International Agency for Research on Cancer (IARC) with

SUBMITTER: Li BH 

PROVIDER: S-EPMC9441794 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature