Prevotella abundance and salivary amylase gene copy number predict fat loss in response to wholegrain diets.

ABSTRACT:

Background

Salivary amylase (AMY1) gene copy number (CN) and Prevotella abundance in the gut are involved in carbohydrate digestion in the upper and lower gastrointestinal tract, respectively; and have been suggested as prognostic biomarkers for weight loss among overweight individuals consuming diets rich in fiber and wholegrains.

Objective

We hypothesized that Prevotella abundance would be linked to greater loss of body fat after wholegrain consumption among individuals with low AMY1 CN, but not in those with high AMY1 CN.

Methods

We reanalyzed data from two independent randomized ad libitum wholegrain interventions (fiber intake ∼33 g/d for 6-8 weeks), to investigate the relationship between baseline Prevotella abundance and body fat los

SUBMITTER: Christensen L 

PROVIDER: S-EPMC9441811 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature