A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility.

ABSTRACT: Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity. Translating these genetic findings into druggable genes that reduce COVID-19 host susceptibility is a critical next step. Using a translational genomics approach that integrates COVID-19 genetic susceptibility variants, multi-tissue genetically regulated gene expression (GReX), and perturbagen signatures, we identified IL10RB as the top candidate gene target for COVID-19 host susceptibility. In a series of validation steps, we show that predicted GReX upregulation of IL10RB and higher IL10RB expression in COVID-19 patient blood is associated with worse COVID-19 outcomes and that in vitro IL10RB overexpression is associated with increased vir

SUBMITTER: Voloudakis G 

PROVIDER: S-EPMC9441828 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature