The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet.

ABSTRACT: The sarco(endo)plasmic reticulum Ca²⁺ ATPase (SERCA) pump is responsible for the transport of Ca²⁺ from the cytosol into the sarcoplasmic reticulum at the expense of ATP, making it a regulator of both muscle relaxation and muscle-based energy expenditure. Neurogranin (Ng) is a small protein that negatively regulates calcineurin signaling. Calcineurin is Ca²⁺/calmodulin dependent phosphatase that promotes the oxidative fibre type in skeletal muscle and regulates muscle-based energy expenditure. A recent study has shown that calcineurin activation reduces SERCA Ca²⁺ transport efficiency, ultimately raising energy expenditure. Since the biomedical view of obesity states that it arises as an imbalance between energy intake and expenditure which favor

SUBMITTER: Braun JL 

PROVIDER: S-EPMC9441848 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature