Circulating sex hormones and risk of atrial fibrillation: A systematic review and meta-analysis.

ABSTRACT:

Background

Sex hormones are associated with many cardiovascular risk factors, but their effects on atrial fibrillation (AF) incidence remain unclear. This systematic review and meta-analysis aimed to evaluate the association of circulating sex hormones with AF risk by pooling available data from observational studies.

Methods

A systematic literature search for pertinent articles with case-control and cohort designs was conducted via five databases up to 7 July 2021. A meta-analysis with six cohort studies was conducted separately on men and women. Adjusted relative risk (RR) with a 95% confidence interval (CI) was derived by comparing the highest with the lowest levels of a specific sex hormone and by using a random-effect or fixed-effect model. Heterogeneity was test

SUBMITTER: Hu P 

PROVIDER: S-EPMC9441879 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature