Nitrogen balance and outcomes in critically ill patients: A systematic review and meta-analysis.

ABSTRACT:

Objective

Nitrogen balance (NB) is a commonly used nutrition indicator in clinical practice, while its relation to the interpretation of protein malnutrition and outcomes in critically ill patients remains unclear. This study aimed to evaluate the impact of NB on prognosis in such a patient population.

Methods

We searched for relevant studies in PubMed, EMBASE, and the Cochrane Database up to May 10, 2022. Meta-analyses were performed to evaluate the relationship between NB (initial, final, or absolute change of NB levels) and prognosis and important clinical outcomes in critically ill patients. Pooled odds ratios (ORs) and mean differences (MDs) together with their 95% confidence intervals (CIs) were calculated. We also conducted subgroup analyses to explore the sources of

SUBMITTER: Zhu YB 

PROVIDER: S-EPMC9441883 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature