Retinal microvasculature and imaging markers of brain frailty in normal aging adults.

ABSTRACT:

Background

The retina and brain share a similar embryologic origin, blood barriers, and microvasculature features. Thus, retinal imaging has been of interest in the aging population to help in the early detection of brain disorders. Imaging evaluation of brain frailty, including brain atrophy and markers of cerebral small vessel disease (CSVD), could reflect brain health in normal aging, but is costly and time-consuming. In this study, we aimed to evaluate the retinal microvasculature and its association with radiological indicators of brain frailty in normal aging adults.

Methods

Swept-source optical coherence tomography angiography (SS-OCTA) and 3T-MRI brain scanning were performed on normal aging adults (aged ≥ 50 years). Using a deep learning algorithm, microvascular tor

SUBMITTER: Tao W 

PROVIDER: S-EPMC9441884 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature