Comprehensive germline and somatic genomic profiles of Chinese patients with biliary tract cancer.

ABSTRACT:

Background

Biliary tract cancer (BTC) is an uncommon but highly lethal malignancy with poor clinical outcomes. To promote the development of precision medicine for BTC, uncovering its genomic profile becomes particularly important. However, studies on the genomic feature of Chinese BTC patients remain insufficient.

Methods

A total of 382 Chinese patients with BTC were enrolled in this study, including 71 with intrahepatic cholangiocarcinoma (ICC), 194 with extrahepatic cholangiocarcinoma (ECC), and 117 with gallbladder carcinoma (GBC). Genetic testing was performed by utilizing the next-generation sequencing (NGS) of 499 cancer-related genes and the results were compared to those of Western BTC patients (MSKCC cohorts).

Results

The most prevalent genes were TP53

SUBMITTER: Yu H 

PROVIDER: S-EPMC9441936 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature