Maternal lead exposure induces sex-dependent cerebellar glial alterations and repetitive behaviors.

ABSTRACT: Lead (Pb) is one of the most prevalent heavy metals we encounter daily. Although there are many reports regarding their toxic effects on humans, the effects of exposure to low lead concentrations throughout the pregnancy period on the offspring are not fully elucidated yet. This study aimed to investigate the cellular mechanisms that occur in response to lead exposure. To this end, we administered lead-containing water to pregnant mice from the day of conception till delivery or till day 28 postnatally. Furthermore, we performed neurodevelopmental disorder-related behavior tests and RNA-sequencing analysis. We used both genders for all experiments because neurodevelopmental disorders usually show several sex-dependent differences. The results revealed increased levels of gliosis in the cer

SUBMITTER: Choi J 

PROVIDER: S-EPMC9442054 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature