Identification of ISCA1 as novel immunological and prognostic biomarker for bladder cancer.

ABSTRACT:

Background

Iron-sulfur cluster assembly 1 (ISCA1) has a significant effect on respiratory complexes and energy metabolism. Although there is some evidence that ISCA1 gene expression impacts energy metabolism and consequently has a role in tumorigenesis and cancer metastasis in different types of malignancies, no systematic pan-cancer study of the ISCA1 has been conducted. As a result, we sought to investigate ISCA1's predictive value in 33 cancer types as well as its possible immunological function.

Methods

We included the pan-cancer expression profile dataset and clinical data from the public database. Firstly, the single-sample Gene Set Enrichment Analysis (ssGSEa) approach was employed for analyzing the immune link in pan-cancer, while the limm

SUBMITTER: Zhou R 

PROVIDER: S-EPMC9442282 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature