LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance.

ABSTRACT: Nuclear receptors are transcription factors with important functions in a variety of physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity using glucocorticoids is a cornerstone in the treatment of patients with T cell acute lymphoblastic leukemia (T-ALL), and resistance to GC-induced cell death is associated with poor outcome and a high risk for relapse. Next to ligand-binding, heterodimerization with other transcription factors presents an important mechanism for the regulation of GR activity. Here, we describe a GC-induced direct association of the Liver Receptor Homolog-1 (LRH-1) with the GR in the nucleus, which results in reciprocal inhibition of transcriptional activity. Pharmacological and molecular interference with LRH-1 impairs proliferation a

SUBMITTER: Michalek S 

PROVIDER: S-EPMC9442305 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature