Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs-NLRC4 association.

ABSTRACT: Inflammasomes are cytosolic multiprotein complexes that initiate host defense against bacterial pathogens. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family caspase-associated recruitment domain-containing protein 4 (NLRC4) inflammasomes plays a critical role in the inflammatory response against intracellular bacterial infection. The NLR family apoptosis inhibitory proteins (NAIPs) detect Flagellin or type III secretion system (T3SS) microbial components to activate NLRC4 inflammasome. However, the underlying mechanism of NLRC4 inflammasome activation is not completely understood. Here, we show that the vitamin D receptor (VDR) is an essential immunological regulator of the NLRC4 inflammasome. Conditional VDR knockout mice (VDR^flox/flox lyz2-Cre) exh

SUBMITTER: Chen X 

PROVIDER: S-EPMC9442308 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature